Docosahexaenoic Acid (DHA), Arachidonic Acid (AA) and Nucleotides DHA and AA are two long chain polyunsaturated fatty acids founds naturally in human milk. Prevalence of DHA and AA in the cerebral cortex has long been established, DHA is widely distribute at high concentration in the central nervous system and thus plays some critical role throughout the central nervous system. DHA intake and status have a significant impact on visual and cognitive development in breastfeed infants. From per capita quantities of food available for the consumption in United State national food supply in 1985, the amount of DHA is 80 mg per capita per day.
Alles, M., S., Scholtens, P., A., M., J. & Bindels, J., G. 2004. Current trends in the composition of infant milk formulas. Current Paediatrics. 14: 51-63.
Brenna, J., T. & Diau, G. Y. 2007. The influence of dietary docosahexaenoic acid and arachidonic acid on central nervous system polyunsaturated fatty acid composition.. Prostagladins, Luekotrienes and Essential Fatty Acids. 77: 247-250.
Carlson, S., E. 2001. Docosahexaenoic acid and arachidonic acid in infant development. Semin Neonatol. 6: 437-449.
Clandinin, M., T., Van Aerde, J., E., Merkel, K., L., Harris, C., L., Springer, M., A., Hansen, J., W. & Diersen-Schade, D., A. 2005. Growth and development of preterm infants fed infant formulas containing docosahexaenoic acid and arachidonic acid. The journal of pediatrics. 146: 461-46. Cosgrove, M. Nucleotides. Nutrition. 14(10): 748- 751.
Du, C., Sato, A., Watanabe, S., Wu, C., Z., Ikemoto, A., Ando, K., Kikugawa, K., Fujii, Y. & Okuyawa, H. 2003. Cholesterol synthesis in mice is suppressed but lipofusci formation is not affected by long-term feeding of n-3 fatty acid-enriched oils compared with lard and n-6 fatty acid-enriched oils. Biol. Pharm. Bull. 26(6): 766-770.
Green, P., Glozman, S., Kamensky, B. & Yavin, E. 1999. Development changes in membrane lipids and fatty acids: the preferential prenatal accumulation of DHA. J. Lipid Res. 40: 960-966.
Hawkes, J., S., Gibson, R., A., Roberton, D. & Makrides, M. 2006. Effect of dietary nucleotide supplementation on growth and immune function in term infants: a randomized controlled trial. Eur. J. Clin. Nutr. 60(2): 254-264.
Lauritzen, L., Hansen, H., S., Jøgersen, M., H. & Michaelson, K., F. 2001. The essentially of long chain omega-3 fatty acids in relation to the development and function of the brain. Prog. Lipid Res. 40: 1-94.
Mazza, M., Pomponi, M., Janiri, L., Bria, P. & Mazza, S. 2007. Omenga-3 fatty acids and antioxidants in neurological and psychiatric diseases: An overview. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 31: 12-26.
McNamara, R., K. & Carlson, S., E. 2006. Role of Omega 3 fatty acids in brain development and function: Potential implication for the pathogenesis and prevention of psychopathology. Prostaglandins, Leukotrienes & Fatty Acids. 75(4- 5): 329-349.
Mitmesser, S., H. & Jensen, C., L. 2007. Roles of long-chain polyunsaturated fatty acids in the term infant